Indeed, although Th17 has been closely linked to the pathogenesis of spondyloarthropathies in patients, IL-27 has been shown to exert it protective effects in a mouse model of collagen-induced arthritis [4], which is a Th17-dependent inflammatory event, but not in adjuvant or proteoglycan-induced arthritis, which are considered Th1-related events [30, 31]. This evidence concerns the gene IL27 and spondyloarthropathy.