ERBB2 and breast cancer: In conclusion, the present study shows that rs78202224 Pro-to-Thr (a missense mutation) is associated with increased breast cancer risk, breast cancer at TT+GT genotype and at T allele, it also show high risk in HER2 negative at TT+GG genotype and T allele, HER2 positive at TT+GG genotype, ER-negative at TT and TT+GG genotype and T allele, PR negative at TT+GG genotype and T allele at TT+GG genotype and T allele.