ADIPOQ and Insulin resistance: In addition, among the three adiponectin isoforms, although a lower HMW/total ratio has been reported to be associated with insulin resistance and T2D [13, 15, 16, 39], indicating that the HMW/total ratio was decreased in T2D subjects, to the best of our knowledge, no studies have examined how the ratio of other adiponectin isoforms to the total adiponectin level might differ in subjects with T2D.