Independent transcriptome analyses of Drosophila epithelia have shown deregulated atf3 expression in wing imaginal discs lacking the conserved neoplastic tumor suppressor genes scribble (scrib) or discs large 1 (dlg1) encoding components of the Scribble polarity module [10], and in rasV12scrib− tumors in the eye/antennal imaginal disc (EAD) [11–13]. The gene discussed is ATF3; the disease is neoplasm.