PPARG and type 2 diabetes mellitus: Several studies have also shown associations of the Pro12Ala variant of PPAR-γ (rs1801282) with obesity, type 2 diabetes/insulin resistance, and metabolic syndrome [9,10,11,12,13], and the PRKAA2 SNP (rs1418442) has also been reported to be associated with serum cholesterol levels in Caucasians [14] and with type 2 diabetes in Japanese populations [2,15].