Importantly, in mice pretreated with MKP-1 siRNA, Gln-mediated attenuation of colitis, i.e., DAI score (Figure 3A), colon length (Figure 3B), and histological inflammation (Figure 3C), and score (Figure 3D), and an increase in colonic levels of TNF-α (Figure 3E) and LTB4 (Figure 3F), were no longer observed. This evidence concerns the gene TNF and colitis.