In a cohort of 32 t(8;21) AML patients with known KIT mutational status, 89.47% (17/19) of those with wild-type KIT were found to have lower expression of miR-130a as compared with the median value of overall miR-130a expression of the 32 t(8;21) patients. The gene discussed is KIT; the disease is acute myeloid leukemia.