Other studies have also demonstrated the ability of TNFα, TRAIL, and IL-12-encoding DNA to induce a therapeutic effect on prostate tumors, but using different modalities of treatment: intra-tumoral injection, use of a virus as a delivery system or co-treatment with mifepristone (Gabaglia et al., 2010), radiotherapy (Fujita et al., 2007), oncolytic herpes simplex viruses (Varghese et al., 2006), adenoviral vector-mediated Herpes Simplex Virus/thymidine kinase and ganciclovir (Nasu et al., 2001). Here, TNF is linked to prostate neoplasm.