When we examined the associations between nulliparity, obesity, HT use and subtypes of HR+ tumors defined by cross‐classification of levels of KI67 and histologic grade (Table 4), we observed nulliparity to be more strongly associated with tumors expressing higher levels of KI67 and this association remained significant after accounting for grade (p‐value = 0.04) and was not modified by grade (p_interaction = 0.37). The gene discussed is MKI67; the disease is obesity due to melanocortin 4 receptor deficiency.