In good agreement with data on SIRT1 activity/expression, the progressive increase in Ac-RARβ level and the concomitant decrease in RARβ in untreated AD mice of 18 and 24 weeks were significantly counteracted by SLAB51 treatment, which restored the 8-week-old AD mice ratio between acetylated and non-acetylated forms (Fig. 2c). Here, RARB is linked to Alzheimer disease.