SIRT1 and Alzheimer disease: Interestingly, the activation of SIRT1-coupled retinoic acid receptor-β (RARβ) attenuated Aβ production in N2a cells expressing human APP Swedish mutation by increasing the activity of a disintegrin and metalloproteinase 10 (ADAM10)/α-secretase, suggesting a protective role for SIRT1 in AD [23].