Similarly, OGG1 levels increased at 18 and 24 weeks of age in untreated AD mice, but in this case SLAB51 was extremely effective in restoring basal levels of 8-week-old untreated AD mice (at 12 weeks, SLAB51 decreased OGG1 levels below basal levels of 8-week-old untreated AD mice) (Fig. 6b). The gene discussed is OGG1; the disease is Alzheimer disease.