In light of our former studies, where observed was a significant reduction in melanoma cell proliferation in effect of N-cadherin silencing, the hypothesis that MMP-9 expression and cellular invasion are governed by at least two, but possibly more, distinct intracellular signalling pathways when stimulated by N-cadherin-FGFR signalling [21], seems to be a sound one. Here, CDH2 is linked to melanoma.