In this study, the miR-144-3p expression was opposite to AQP1 expression in LPS-induced ALI mice lung tissue and lung epithelial cell (Figs. 1b and 2b), and the luciferase reporter assay revealed that AQP1 was a target of miR-144-3p (Fig. 6). Here, AQP1 is linked to acute respiratory distress syndrome.