As AQP1 expression was opposite to miR-144-3p expression in ALI mice and LPS-induced A549 cell, and the AQP1 was predicted to be a target of miR-144-3p (Fig. 6a), so we performed the luciferase reporter assay to verify that whether miR-144-3p could bind to 3′UTR of AQP1. Here, AQP1 is linked to acute respiratory distress syndrome.