BRAF and metastatic neoplasm: For instance, patients with mutation in the BRAF V 600 E gene and melanoma patients with KIT gene abberration represent two subgroup responsive respectively to the action of BRAF inhibitors and cKit blockersBRAF inhibitors, such as PCV4032 and RAF 265, induce tumour regression in up to 70% of patients with metastatic disease, whereas cKit blockers includes Imatinib, dasatinib, sunitinib and sorafenib [121].