RIPK1 and hepatocellular carcinoma: Research showed that RIPK1 deletion could induce TNF-mediated hepatocyte apoptosis without affecting the expression of NF-κB, and at the same time RIPK1 deletion in liver parenchymal cells promoted degradation of TNF receptor-associated factor 2 (TRAF2) resulting in liver damage, suggesting that deletion of RIPK1 and degradation of TRAF2 together promoted the development of HCC [70].