However, increased levels of caspase-3 were significantly associated with PR status (–/+) (OR = 1.44, 95%CI 1.09–1.89) and HER-2 status (–/+) (OR = 1.76, 95%CI 1.18–2.62) in breast cancer [46, 47]. Here, ERBB2 is linked to breast carcinoma.