It is easy to find that there are three different race patients are included for the present study, however, the pooled HR of Asian patient (HR = 3.16, 95%CI 1.20–8.35) showed caspase-3 to be a risk factor, the combined HR of European and American revealed the expression of caspase-3 had no significant difference between breast cancer and normal sample (HR = 1.16, 95%CI 0.79–1.70 and HR = 1.75, 95%CI 0.24–12.88,separately). Here, CASP3 is linked to breast cancer.