Random-effects models were adopted for the risk assessment of all three clinicopathological parameters (tumor differentiation grade, lymph nodes metastases and Tumor TNM stage) with caspase-3 because of the high study heterogeneity (P = 0.00, I2 = 90.4%; P < 0.001, I2 = 67.6%; P = 0.021, I2 = 53.9%, respectively). Here, CASP3 is linked to neoplasm.