Vegran F and colleges measured caspase-3 expression by reverse transcription-PCR in 130 invasive ductal breast carcinomas and found that caspase-3 levels were higher in carcinoma tissues than in corresponding non-neoplastic tissues, but up-regulation of caspase-3 had no significant association with DFS (HR = 1.04, 95%CI 0.61–1.79). Here, CASP3 is linked to invasive ductal breast carcinoma.