However, no evidence showed that up-regulation of caspase-3 expression was correlated with lymph node metastasis (–/+) (OR = 0.78, 95%CI 0.53–1.16, Figure 5A), tumor differentiation grade (low, moderate or high) (OR = 0.49, 95%CI 0.19–1.27, Figure 5B) or tumor TNM stage (OR = 0.77, 95%CI 0.45–1.32, Figure 5C). This evidence concerns the gene CASP3 and metastatic malignant neoplasm in the lymph nodes.