In a first phase (elimination phase), the stimulated immune system produced many costimulating cytokines (TNFα, IL1, IFNα, TLR, ICAM1, IL2, IL12, IFNγ,) and less inhibitors (IL10, IL4, IL13, PD1/PD-L1, prostaglandins, LAG-3, TGFβ) resulting in efficient tumor cell killing. Here, PDCD1 is linked to neoplasm.