PD-L1 expression was significantly associated with older age (p = 0.04), right sided location (p = 0.004), medullary histology (p < 0.001), G3 tumor grade (p < 0.001), sporadic tumor associated neutrophils (TANs) (p = 0.003), BRAF mutation (p = 0.001), and MSI (p = 0.003). The gene discussed is CD274; the disease is neoplasm.