In this study, we tried to assess the existence of any correlation between mutations in the main genes involved in melanoma initiation and progression (BRAF, NRAS, CDKN2A) and copy number variations in a subset of candidate genes (MITF, EGFR, CCND1, cMET, and cKIT) already demonstrated at single level to be amplified during melanoma pathogenesis. The gene discussed is EGFR; the disease is melanoma.