MITF and melanoma: Melanoma cell lines were investigated for the ploidy pattern at genomic loci of five candidate genes involved in melanocytic transformation and progression by a two-colour fluorescence in situ hybridization (FISH) analysis, using five genomic subclones as probes spanning the following chromosomal regions: MITF at chromosome 3p14.1, EGFR at 7p11.2, CCND1 at 11q13.2, cMET at 7q31.2, and cKIT at 4q12.