Previously a single intra-peritoneal injection of 10 mg/kg ZnCl2 into SCID mice has been shown to increase free intracellular Zn2+ and induce gastrin gene expression in colon cancer cells grown as xenograft tumours [21] and two subcutaneous injections of 10 mg/kg ZnCl2 into rats protects against renal ischemia reperfusion injury [11]. This evidence concerns the gene GAST and colonic neoplasm.