A recent study addresses the tumor microenvironment of HNSCC focusing on immune cell infiltration with a low neutrophil-to-lymphocyte ratio predicting a better response to induction chemotherapy [20] which is in accordance with our data that suggest a positive effect of a high tumoral T-cell infiltrate on control of metastasis and an adverse prognostic effect of high tumoral CD11b expression. The gene discussed is ITGAM; the disease is neoplasm.