Indeed, we found that the effect of sorafenib on protein biosynthesis correlates with the inhibition of 4EBP1 phosphorylation, a well-established target of mTOR cell signaling [39, 40] We explored the consequences of this inhibition of translation, and report here that global protein biosynthesis modulates the UPR in HCC cells. The gene discussed is MTOR; the disease is hepatocellular carcinoma.