The effect of VQ-1 may be inhibited by the transient receptor potential cation channel, subfamily M, member 7 (TRPM7) being activated by ATP in the tumor environment [13] and it can be hypothesized that the models used in this study may be vulnerable to a simultaneous administration of TRPM7 inhibitory compounds and VQ-1. The gene discussed is TRPM7; the disease is neoplasm.