We believe that our compound, JMS-053, along with other small molecules that have recently been described [7], will likely be useful in testing the hypothesis that the pharmacological inhibition of PTP4A3 can suppress OvCa by targeting both the tumor cell directly and endothelial cell hyperpermeability, which enables the infiltration of cells and soluble proteins into the tumor microenvironment and results in an accumulation of ascites fluid. This evidence concerns the gene PTP4A3 and neoplasm.