To determine whether this innate response is cancer type specific, we generated IDTCs from NRAS mt melanoma (WM1366), KRAS mt lung (A549), PIK3CA mt breast (SKBR3), and KRAS mt colon (HT29) cancer cell lines by exposing them to sub-lethal concentrations of either chemotherapy or specific targeted therapies. This evidence concerns the gene KRAS and melanoma.