In case of approximately 90% of AdCC samples, more than 58% of the cells exhibited strong 2+ reactivity for C-kit, whereas 42% of the lesions showed moderate staining in about 20-50 % of the cells and were graded as 1+.CD117 showed mainly diffuse cytoplasmic staining with weak membranous component. The gene discussed is KIT; the disease is adrenocortical carcinoma, hereditary.