STUB1 and cerebellar ataxia: Whole exome sequencing studies have established that homozygous mutations in the E3 ligase STIP1 homology and U-Box containing protein 1 (STUB1) also known as carboxy terminus of Hsp70-interacting protein (CHIP), results in ataxia and hypogonadism with a frequency of 2.3% in GHS patients (Shi et al., 2014; Hayer et al., 2017; Figure 3 and Supplementary Table 2).