UBE3A and Global developmental delay: It is worth noting duplication of the 15q11-q13 region of the maternal chromosome harboring the UBE3A gene is also a common and highly penetrant factor of autism spectrum disorder (ASD) pathogenesis (Figure 1 and Supplementary Table 1), and an increased dosage of the UBE3A gene is associated with developmental delay and neuropsychiatric phenotypes (Cook et al., 1997; Glessner et al., 2009; Noor et al., 2015).