The role of RNF213 in MMD was examined by subjecting WT mice to transient middle cerebral artery occlusion (tMCAO) and measuring mRNA expression of RNF213 both by in situ hybridization and RT-PCR, finding that RNF213 was upregulated compared to controls and its expression was predominantly in neurons (Sato-Maeda et al., 2016). Here, RNF213 is linked to multiminicore myopathy.