While only 1% of tumor tissue is composed of malignant Reed–Sternberg (RS) cells, the remaining 99% of cHL tissue comprises the TME and includes numerous inflammatory cells including B-cells, T-cells [CD4+ T-helper cells, regulatory T-cells (Tregs), and cytotoxic CD8+ T-cells], macrophages, eosinophils, neutrophils, plasma cells, dendritic cells, and fibroblasts, all meticulously orchestrated by the dysregulated secretion of chemokines and cytokines from both TME and RS cells (11). This evidence concerns the gene CD8A and classic Hodgkin lymphoma.