In the first part of the article, we present how Fe-S clusters are formed, a process that has been studied extensively by biochemists in prokaryotes (Roche et al., 2013; Blanc et al., 2015), yeast (Martinez-Pastor et al., 2017), plants (Balk and Schaedler, 2014), and humans (Paul and Lill, 2015; Rouault and Maio, 2017), but also by the biomedical community intent to find a therapy for patients with Friedreich's ataxia, caused by reduced expression of the frataxin (FXN) gene (Campuzano et al., 1996). This evidence concerns the gene FXN and Friedreich ataxia.