NFKB1 and rheumatoid arthritis: It primarily attenuates inflammatory response in RA by inhibiting NF-κB, NF-κB/TNF-α/vascular cell adhesion molecule-1, and TGF-β1/α-smooth muscle/vimentin signaling pathways induced by TNFs and TLR4 (Huang J. et al., 2015; Gong et al., 2017).