In breast cancer, Pece et al. (2010) have demonstrated that the signature of human normal mammary stem cells is able to stratify breast cancers (basal tumors from the other subtypes) and that CD49F+/DLL1H/DNERH cells but not DNERL, both from poorly and well-differentiated tumors, are enriched in stem cells, as they can generate PD3D cell cultures and tumors in immunodeficient mice. This evidence concerns the gene ITGA6 and breast cancer.