In addition, the diagnosis of PCOS can only be made once other causes have been excluded3; therefore, a biomarker or combination of biomarkers to allow a positive diagnosis of PCOS is of major interest to help make a positive diagnosis of PCOS and to reduce the uncertainty that may result for individual patients; AMH has been suggested to be such a biomarker6,12. This evidence concerns the gene AMH and polycystic ovary syndrome.