At cg18584561 (GREB1), which was trimodal, both the hypomethylated and hypermethylated peaks were associated with decreased breast cancer risk (OR = 0.60 (95% CI: 0.45–0.80), and OR = 0.56, (95% CI: 0.34–0.95), respectively). The gene discussed is GREB1; the disease is breast cancer.