In the present study Dox@PVP-AuNPs complex enhances the expression of caspase 9 and caspase 3 and AO/EB staining assay confirmed the apoptosis in lung cancer by emitting red color fluorescence in Dox@PVP-AuNPs chromatin condensation and formation of apoptotic bodies by bright blue fluorescence. The gene discussed is CASP3; the disease is lung cancer.