In the present study, we also demonstrated the anticancer activity doxorubicin conjugated with PVP coated AuNPs against A549, H460 and H520 lung cancer cells and results indicated that Dox@PVP-AuNPs effectively inhibit the proliferation of lung cancer cells and induces p53 mediated mitochondria dependent apoptosis. The gene discussed is TP53; the disease is lung cancer.