In vivo, M3R is expressed in a number of tissues17 and regulates many important physiological and pathological conditions, including smooth muscle contraction and dilation of peripheral blood vessels18, cardiac function and heart disease19, whole-body metabolic activities20, insulin secretion21, bone formation22, tumor formation in the gastrointestinal tract23, T-cell dysfunctioning in Sjögren’s syndrome24, and others25. The gene discussed is INS; the disease is neoplasm.