(i) The tumor suppressor PTEN competes with F-box/LRR-repeat protein 2 (FBXL-2), an E3 ubiquitin ligase component belonging to the Skip-Cullin1-F-box protein family112, for binding to IP3R3, thereby slowing down FBXL-2-mediated proteasomal degradation of IP3R3113. Here, ITPR3 is linked to neoplasm.