Therefore, in order to determine the net effect of MDSCs on RA, we performed adoptive transfer using three types of MDSCs (total MDSCs:CD11c-CD11b+GR-1+ cells, M-MDSCs:CD11c-CD11b+ Ly6G-Ly6Chigh cells, G-MDSCs:CD11c-CD11b+ Ly6G+ Ly6Clow cells) in CIA mice. The gene discussed is ITGAX; the disease is rheumatoid arthritis.