We found that T-bet was upregulated in tumor-infiltrating CD3+CD8+ T cells upon CQ treatment, whereas the expression of PD1/CTLA-4 was downregulated in CD3+CD8+T-bet+ T cells (Supplementary Fig. 3c), consistent with previous report that T-bet represses PD-1 expression27. Here, CTLA4 is linked to neoplasm.