CTLA4 and melanoma: We found that the inhibitory effect of CQ on the growth of B16 melanoma and H22 hepatocarcinoma was enhanced by IPI-549, along with further depression of T-cell PD1 and CTLA-4 expression (Supplementary Fig. 4k-m), suggesting that PI3Kγ inhibition has a synergistic effect on CQ-triggered antitumor immunity.