SOD1 and amyotrophic lateral sclerosis: By performing subcellular fractionation in samples from a neuronal cell line overexpressing mutated SOD1 and from the spinal cord of SOD1 ALS mice, Watanabe et al.36 found different forms of mutated SOD1 enriched in both the mitochondrial and MAMs fractions, which was not observed for wild-type SOD136.