UBQLN2 and amyotrophic lateral sclerosis: Multiple ALS-associated genes, including sequestosome 1 (also known as the ubiquitin-binding protein p62) (SQSTM1), optineurin (OPTN), ubiquilin 2 (UBQLN2), and valosin containing protein (VCP), encode proteins regulating autophagy processes96–99.