The identified top M2 hub proteins also include all three members of the ezrin-radixin-moesin (ERM) family, ezrin (EZR), radixin (RDX), and moesin (MSN), which were up-regulated in AD (Fig. 6 and Additional file 2: Table S2), suggesting a role of ERM proteins in AD. The gene discussed is EZR; the disease is Alzheimer disease.