The M12 module was also significantly enriched with neurofilament proteins (NEFL, NEFM, and INA) and microtubule-binding proteins involved in the control of microtubule polymerization or stabilization (CRYAB, MAPRE1, DST, CRMP2/DPYSL2, CLASP2, and MAP1B) and axonal transport (DCTN1 and DCTN4), indicating an association of impaired neurofilament and microtubule functions with Tau aggregation in AD. Here, MAPRE1 is linked to Alzheimer disease.