The M2 module was also highly enriched with proteins involved in the unsaturated fatty acid metabolic process (ACAA1, ACOX1, EPHX2, HSD17B4, LTA4H, PTGDS, PTGR1, PTGR2, GSTM2, GSTM3, GSTP1, and MIF), highlighting a link between dysregulated unsaturated fatty acid metabolism and AD pathophysiology. The gene discussed is HSD17B4; the disease is Alzheimer disease.