M11, a 62-member module negatively correlated with AD phenotypes (Fig. 4), has heterotrimeric G-protein subunits (GNAI1, GNAI2, GNAI3, and GNAO1) and Src family of tyrosine kinases (FYN and YES1) as top hub proteins (Fig. 7), highlighting the involvement of altered intracellular signaling in AD pathophysiology. Here, GNAI3 is linked to Alzheimer disease.