In addition, the M13 module was also significantly enriched with GO terms and proteins linked to organization of the actin cytoskeleton (ARPC1A, CFL1, CFL2, CTTN, RAC1, PAFAH1B1, NF1, SPTAN1, and SPTBN2) and microtubule cytoskeleton (MAPRE3, KLC2, NIT2, TBCA, TUBA8, MAP7D1) (Fig. 7 and Additional file 6: Table S6), supporting the involvement of impaired actin and microtubule dynamics in AD pathophysiology [5, 25]. Here, SPTAN1 is linked to Alzheimer disease.