M16, a 55-member, AD-positively correlated module (Fig. 4), was significantly enriched with GO categories and proteins linked to inflammatory response (C3, FHL1, A2M, CD44, FN1, HP, SERPINA1, and SERPINA3) with complement C3 and alpha-2-macroglobulin (A2M) as top hub proteins (Fig. 6 and Additional file 6: Table S6). The gene discussed is C3; the disease is Alzheimer disease.