The M2 module was also highly enriched with proteins involved in the unsaturated fatty acid metabolic process (ACAA1, ACOX1, EPHX2, HSD17B4, LTA4H, PTGDS, PTGR1, PTGR2, GSTM2, GSTM3, GSTP1, and MIF), highlighting a link between dysregulated unsaturated fatty acid metabolism and AD pathophysiology. Here, ACOX1 is linked to Alzheimer disease.