Another key molecular feature of M16 module is significant overrepresentation of extracellular matrix proteins (COL6A1, COL6A2, COL6A3, COL18A1, LAMA5, FLNA, and FLNB) as hub proteins (Fig. 6), providing evidence for the involvement of extracellular matrix dysfunction in AD [49]. Here, FLNA is linked to Alzheimer disease.