DPYSL3 and Alzheimer disease: In addition, the M11 module was significantly enriched with GO terms and proteins linked to regulation of actin cytoskeleton (CRMP1, CRMP4/DPYSL3, ABI1, FSCN1, and WASF1) and microtubule cytoskeleton (TUBAL3, TBCB, NDRG1, NDRG2, SHTN1, and SNCG) (Fig. 7 and Additional file 6: Table S6), consistent with impaired actin and microtubule dynamics in AD brain [5, 25].