Thus, early long-term administration seems to be crucial to significantly reduce amyloid pathology, since other investigators have reported that PLX3397 and other CSF1R inhibitor-induced ablation of microglia does not cause a reduction in amyloid plaque load when treatment is initiated at later times after robust amyloid plaque deposition in 5XFAD mice [10]. Here, CSF1R is linked to amyloidosis.