We assessed CD74 expression levels in tumor cell lines from different entities (H1 and H1_DL2 (brain seeking cell line from melanoma BM), SKMEL-2 (skin metastatic melanoma), SKMEL-28, UACC-257 (both melanoma), MDA-MB-231, Jimt1 (both brain seeking clones of pleural metastatic breast cancer), PC-14 (brain seeking clone of lung adenocarcinoma)). The gene discussed is CD74; the disease is neoplasm.