CD74 siRNA knockdown in H1 brain metastatic cells (Fig. 5a-d) did not influence HLA class II expression on protein level (Fig. 5a), transcriptional level (as assessed by TaqMan® array designed for the detection of the human antigen processing and presentation machinery by HLAs (Fig. 5f) corroborated by RNA-microarray (Fig. 5g)) nor did it influence HLA class II expression on the tumor cell surface as assessed by FACS analysis (Fig. 5e). Here, HLA-S is linked to neoplasm.