INS and Insulin resistance: In PCOS, insulin sensitivity is thought to regulate the expression of glucose transporters in granulosa cells by reducing glucose uptake within the oocyte, thereby also reducing the resources available for energy metabolism [3].The insulin receptor sensitizer substance acts as an intracellular second messenger, regulating the activities of insulin and glucose metabolism and transport [4] and decreasing hyperandrogenism and insulin resistance in PCOS women [5].However, the exact mechanisms through which an increase in androgen levels leads to ovulation disorder are not yet fully understood.