In models of human immune cells in culture, selected for their relevance to the pathogenesis of rheumatoid arthritis, CR6086 markedly decreased PGE2-mediated IL-23 release from human dendritic cells, IL-17 release from human Th17 cells, and IL-6 and VEGF transcription in human macrophages. The gene discussed is VEGFA; the disease is rheumatoid arthritis.