On conducting an analysis of the study population, the circulating levels of ANGPTL4 (202.49 ± 17.44 ng/mL vs. 160.64 ± 10.36 ng/mL, p = 0.04) and ANGPTL8 (2310.96 ± 194.88 pg/mL vs. 1583.35 ± 138.27 pg/mL, p = 0.001) were higher in subjects with hypertension than in those without hypertension, whereas ANGPTL3 (70.34 ± 3.42 ng/mL vs. 68.35 ± 5.47 ng/mL, p = 0.76) levels were not different between the two groups (Fig. 1a, b & c). The gene discussed is ANGPTL8; the disease is hypertensive disorder.