We began by infecting mice with either lethal (1e8 colony-forming unit [CFU]) or sublethal (5e7 CFU) numbers of S. aureus in the presence of AT-neutralizing monoclonal antibody (mAb) MEDI4893* and monitoring bacterial clearance and IL-1β levels in the airway 4 and 24 hr post-infection. The gene discussed is IL1B; the disease is infection.