PDK1 and gastric cancer: For example, miRNA-375 isdownregulated in gastric carcinomas and regulates cell survival by targeting PDK1 and14-3-3ζ (14), miRNA-7 functions as ananti-metastatic miRNA in GC by targeting insulin-like growth factor-1 receptor (15), and miR-148a contributes to the maintenance ofhomeostasis in normal stomach tissue and plays an important role in GC invasion byregulating MMP7 expression.