Association of SNPs in vascular endothelial growth factor (VEGF), IL-6, IL-10, IL-1beta, interferon alpha, TNF-alpha genes with immunoregulatory function revealed that C allele of VEGF, an allele of IL-10 and GG genotype of TNF-alpha, was individually associated with chronic periodontitis.10 Here, IL1B is linked to periodontitis.