SPRY4 and central nervous system cancer: More importantly, SPRY4-IT1 overexpression was associated with poor prognosis in various types of human malignancies such as renal cancer [12], ESCC [11], gastric cancer [14], bladder cancer [15], HCC [16], glioma [17], cervical cancer [18], colorectal cancer [19], ovarian cancer [20], and lung cancer [21].