We previously described down-regulation of the VDR-target gene CYP27B1 by IL-6 and tumour necrosis factor alpha (TNF-α) in the COGA-1A colon cancer cell line, implying that pro-inflammatory cytokines might impair VDR activation, thereby limiting its anti-inflammatory action [6]. The gene discussed is CYP27B1; the disease is colonic neoplasm.