To study the important role of pDC in immune response and immune disorders, different human leukemic pDC lines e.g. CAL-1, GEN2.2 and PMDC05 with characteristic pDC phenotype and function were generated.[8–10] However, stable cell lines of murine pDC that display characteristics comparable to that of primary pDC are missing. The gene discussed is PDC; the disease is immune system disorder.