We have identified a decrease in the levels of CRBN following ND-13 treatment (ND-13: 1.77E+07 ±3.55E+06; Vehicle: 1.19E+08 ±2.52E+07; fold change: 6.7, p<0.01; Fig 6A), suggesting an increase in the surface expression of functional KB channels that, in turn, improve the survival of cells after ischemia. The gene discussed is CRBN; the disease is ischemia.